Vitamin B3 Nicotinamide (Niacinamide) 500mg 180 Capsules (V) Vegan. No-Flush Niacinamide. Made in The UK by Health4All

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Mainville L, Smilga AS, Fortin PR. Effect of nicotinamide in skin cancer and actinic keratoses chemoprophylaxis, and adverse effects related to nicotinamide: a systematic review and meta-analysis. J Cutan Med Surg. 2022;26(3):297-308. doi:10.1177/12034754221078201. Nijkamp MM, Span PN, Terhaard CH, Doornaert PA, Langendijk JA, van den Ende PL, de Jong M, van der Kogel AJ, Bussink J, Kaanders JH. Epidermal growth factor receptor expression in laryngeal cancer predicts the effect of hypoxia modification as an additive to accelerated radiotherapy in a randomised controlled trial. Eur J Cancer. 2013 Oct;49(15):3202-9. View abstract.

Nicotinamide | DermNet Nicotinamide | DermNet

Niacinamide is generally considered safe with few side effects at appropriate doses. It’s available as a dietary supplement and is a common ingredient in skin care products.

How does nicotinamide work?

Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your needs. Chen AC, Martin AJ, Choy B, et al. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention. N Engl J Med. Oct 22 2015;373(17):1618-1626. In supplements, niacinamide might be listed on the label in niacin equivalents (NE). 1 mg of niacinamide is the same as 1 mg NE. Niacinamide is found in many vitamin B complex supplements with other B vitamins. It's also used in many topical creams and gels.

Nicotinamide | Memorial Sloan Kettering Cancer Center Nicotinamide | Memorial Sloan Kettering Cancer Center

Preclinical models demonstrate photoimmunoprotective and chemopreventive effects against UV radiation (4). Nicotinamide enhances repair of UV radiation-induced DNA damage in human melanocytes (5) and keratinocytes (6) and similar effects have been demonstrated in human studies (4) (7) (8). It was also shown to improve inner retinal (27) and visual function (28) in patients treated for glaucoma. Other clinical trials show oral nicotinamide reduces UV-induced (9) and photodynamic therapy (PDT)-induced (10) immunosuppression. El‐Khalawany M, Nouh AH, Kadah AS, Elsheikh M, Said M. Evaluation of safety and efficacy of topical 4% nicotinamide in treatment of psoriasis; among a representative sample of Egyptians (An analytical observational study). Dermatologic Therapy. 2022;35(9). doi:10.1111/dth.15734 Pozzilli P, Visalli N, Cavallo MG, et al. Vitamin E and nicotinamide have similar effects in maintaining residual beta cell function in recent onset insulin-dependent diabetes. Eur J Endocrinol 1997;137:234-9. View abstract. Hrubša M, Siatka T, Nejmanová I, et al. Biological properties of vitamins of the B-complex, part 1: vitamins B1, B2, B3, and B5. Nutrients. 2022;14(3):484. doi:10.3390/nu14030484High levels of phosphate in the blood (hyperphosphatemia). In people who need hemodialysis due to kidney failure and have high levels of phosphate, taking niacinamide by mouth seems to help decrease phosphate levels. Safety considerations: Rash, stomach upset, elevated liver enzymes (at more than 3 grams (g) per day, though this is rare), thrombocytopenia (in people who have renal disease and are on dialysis).

Vitamin B3 Nicotinamide (Niacinamide) 500mg | Health4All Vitamin B3 Nicotinamide (Niacinamide) 500mg | Health4All

Thanos SM, Halliday GM, Damian DL. Nicotinamide reduces photodynamic therapy-induced immunosuppression in humans. Br J Dermatol. Sep 2012;167(3):631-636. Phosphate levels are otherwise typically managed through diet, medications or dialysis, depending on the severity of the buildup ( 20). May Slow the Progression of Type 1 DiabetesNiacin (vitamin B3) is a very important nutrient for your body. It has many health benefits, along with several side effects if you take large doses… READ MORE

British Association of Dermatologists

A combination of oral nicotinamide and tetracycline appears to be a useful alternative to systemic steroids in the treatment of bullous pemphigoid. It is less toxic and safer than dapsone and prednisone. While promising, more research is needed before niacinamide supplements can be recommended as an intervention for type 1 diabetes. SummaryHuber R, Wong A. Nicotinamide: an update and review of safety & differences from niacin. Skin Therapy Lett. 2020;25(5):7-11.